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From the CHEST 1 study, 261 patients with inoperable CTEPH or with persistent or recurrent pulmonary hypertension after PEA were randomized and treated with either riociguat or placebo orally for 16 weeks. Riociguat was titrated, during a period of 8 weeks in doses of 0.5 mg increments, from 1.0 mg up to 2.5 mg, three times on a daily basis. Following your titration phase, patients were followed up for the next 8 weeks on the last dose to try and do CHEST 1.

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