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Treatment discontinuation caused by AEs was reported in 11 percent of patients.Abstract 4471: IMBRUVICA in MCL Patients Who Progressed after Rituximab Containing Regimen and BortezomibA second poster presented by Wang today reported on data from the Phase 2, multicenter, single arm study (SPARK) evaluating once daily IMBRUVICA (560mg) in patients experiencing relapsed/refractory MCL who had received a rituximab containing ghd australia jewelry 1 on 1 treatment regimen along progressed after not less than two cycles of bortezomib. After the median followup of 14.9 months, ORR (the leading endpoint) ghd australia 500 500 as assessed by an unbiased Review Committee (IRC) was 62.7 percent (95 % CI, 53.7 percent 71.8 percent) and 20.9 % achieved an extensive response (CR).Amount of response (DOR), PFS, OS and safety were key secondary endpoints. Many people had stage IV disease (77.5 percent) and 76.3 % of an individual were regarded as at intermediate or high-risk, depending on the Mantle Cell Lymphoma International Prognostic ghd abs repair leaky Index (MIPI).

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