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Treatment discontinuation due to AEs was reported in 11 percent of patients.Abstract 4471: IMBRUVICA in MCL Patients Who Progressed after Rituximab Containing Regimen and BortezomibA second poster presented by Wang today reported on data from your Phase 2, multicenter, single arm study (SPARK) evaluating once daily IMBRUVICA (560mg) in patients living alongside relapsed/refractory MCL who had received a rituximab containing treatment regimen coupled with progressed after not less than two cycles of bortezomib. Following a median follow up of 14.9 months, ORR (the key endpoint) as assessed by persistent Review Committee (IRC) was 62.7 percent (95 % CI, 53.7 percent 71.8 percent) and 20.9 percent achieved a total response (CR).Amount of response (DOR), PFS, OS and safety were key secondary endpoints. Most people had stage IV disease (77.5 percent) and 76.3 percent of folks were thought to be at intermediate or dangerous, based on the Mantle Cell Lymphoma International Prognostic Index (MIPI).

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